Wafik S. El-Deiry: Our long-awaited manuscript describing the IC50-Seeding Density Slope

Wafik S. El-Deiry shared on LinkedIn:

“Pleased to share our long-awaited manuscript describing the IC50-Seeding Density Slope (ISDS), aka the “Ujwal-WAF index”

Ujwal Punyamurtula, Thomas W Brown, Shengliang Zhang, Andrew George, Wafik S El-Deiry: Cancer cell seeding density as a mechanism of chemotherapy resistance: a novel cancer cell density index based on IC50-Seeding Density Slope (ISDS) to assess chemosensitivity. Am J Cancer Res 2023;13(12):5914-5933.”

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Source: Wafik S. El-Deiry/LinkedIn

Wafik El-Deiry, MD, PhD, FACP, FRSM, an American Cancer Society Research Professor, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. This has been the most highly cited original work published in Cell.

He discovered TRAIL receptor DR5 as a p53 target, and ONC201/TIC10 as a TRAIL pathway, integrated stress response inducer, and cancer therapeutic with efficacy in diffuse midline glioma and other tumors.  He was named one of America’s Top Oncologists by the Consumer Res Council of America in 2008 and 2009. He is a practicing physician-scientist specializing in colorectal cancer treatment.