John Simmerling: Amazing molecular animation video on an activated T-cell engaging with a diseased cell
John Simmerling, Chief Science Officer at Biomedical and Healthcare Technology Solutions Group, shared a post on LinkedIn:
“This amazing molecular animation video from WEHI (Walter and Eliza Hall Institute of Medical Research) shows an activated T-cell engaging with a diseased (or malignant) cell – then activating apoptotic pathways – a stunning cascade of molecular processes seen in mitochondrial cascades and death receptor cascades.
Cytotoxic T cells specialize in apoptosis initiation, while other immune cells, such as macrophages and neutrophils, predominantly perform phagocytosis.
While engulfment is effective, it’s not specialized enough for precision therapies, such as engineered antibody therapies like CAR-T.
CAR-T cells used in cancer treatment express an engineered receptor that explicitly recognizes a tumor-associated antigen on the surface of malignant cells.
CAR-T treatments are often combined with other therapies to overcome extreme cytokine reactions (using tocilizumab or corticosteroids) and the expression of PD-1/PD-L1 to evade detection (using anti-PD-1 antibodies like pembrolizumab).
Permission to use this video is granted under specific educational and social media terms in the licensing for WEHI (Walter and Eliza Hall Institute of Medical Research).”
Proceed to the video attached to the post.
John Simmerling is the Chief Science Officer at the Biomedical and Healthcare Technology Solutions Group. Previously, he served as Chief Science Officer for the Infectious Disease Biotechnology Organization.
His career includes leadership roles such as Senior Business Development Manager for Precision Medicine in Oncology at Philips and Regional Vice President and Subject Matter Expert in Medical and Radiation Oncology Pathways at NantHealth.
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