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Neoadjuvant nivolumab and relatlimab in locally advanced MSI CRC
Nov 16, 2024, 15:57

Neoadjuvant nivolumab and relatlimab in locally advanced MSI CRC

Arndt Vogel, Managing Senior Consultant and a Professor in the Department of Gastroenterology, Hepatology, and Endocrinology at Hannover Medical School, shared an article by Peter G. M. de Gooyer on X:

“Neoadjuvant nivolumab & relatlimab in locally advanced MSI CRC.

  • NICHE-3 phs 2.
  • PR 97%, MPR 92%, pCR 68%.
  • only one recurrence.
  • Gr 3–4 irAEs 10%.
  • Impressive, we need to find the most effective, least toxic combination.

 

Neoadjuvant nivolumab and relatlimab in locally advanced MSI CRC

Neoadjuvant nivolumab and relatlimab in locally advanced MMR-deficient colon cancer: a phase 2 trial.

Authors: Peter G. M. de Gooyer, et al.

Neoadjuvant nivolumab and relatlimab in locally advanced MSI CRC

Arndt Vogel, MD, is a Managing Senior Consultant and a Professor in the Department of Gastroenterology, Hepatology, and Endocrinology at Hannover Medical School. Leading the GI-Cancer Center and the Center for Personalized Medicine, his research focuses on translational and clinical studies in gastrointestinal cancer. He’s actively engaged in various societies including ESMO, ASCO, and EASL. Additionally, he chairs the Hepatobiliary Cancer Study Group of the AIO, contributing significantly to clinical oncology in Germany. Within ESMO, he serves on the Guidelines Steering Committee.