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The role of PDOs as preclinical models in gene editing for guiding personalized treatment
Nov 12, 2024, 01:16

The role of PDOs as preclinical models in gene editing for guiding personalized treatment

Vivek Subbiah, Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute, shared an article by Le Tong on LinkedIn:

“Patient-derived organoids in precision cancer medicine was published in MED at Cell Press journals.

  • Organoids are three-dimensional (3D) cultures, normally derived from stem cells, that replicate the complex structure and function of human tissues.
  • This review covers the role of PDOs as preclinical models in gene editing, molecular profiling, drug testing, and biomarker discovery and their potential for guiding personalized treatment.”

Patient-derived organoids in precision cancer medicine.

Authors: Le Tong, et al.

The role of PDOs as preclinical models in gene editing for guiding personalized treatment

Vivek Subbiah is the Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute (USA). He is the former Executive Director of Oncology Research and former Associate Professor in the Department of Investigational Cancer Therapeutics at the MD Anderson Cancer. He focuses on translational cancer research and the design and implementation of early-phase biomarker-driven clinical trials. His work specifically targets antibody-drug conjugates, radiopharmaceuticals, immunoconjugates, and basket trials. He has also received the Yvonne Award 2024 by OncoDaily in the “Voice of Oncology” category.