Dual-function Stem-like T Cells in Tumor Immunity
Cancer Research Institute (CRI) shared a post on LinkedIn:
“Exciting findings from CRI Lloyd J. Old STAR Dr. Haydn Kissick of Emory University reveal a unique, stem-like T cell population with a surprising dual role, that can either suppress, or activate tumor-fighting T cells. In tumor-draining lymph nodes, these PD1+TCF1+ CD4 T cells switch character based on their surroundings.
They remaining stem-like in the presence of regulatory T cells (T regs) to limit tumor immune responses, or transform into T helper 1 (TH1) cells to activate tumor fighting CD8+ T cells for stronger tumor control when T regs are absent. This discovery opens new doors to understanding how to harness these T cells in order to improve cancer therapies. Explore.”
Differentiation fate of a stem-like CD4 T cell controls immunity to cancer
Authors: Maria A. Cardenas, Nataliya Prokhnevska, Ewelina Sobierajska, Petra Gregorova, Christopher B. Medina, Rajesh M. Valanparambil, Rachel Greenwald, Luke DelBalzo, Mehmet Asim Bilen, Shreyes Joshi, Vikram Naryan, Viraj A. Master, Martin G. Sanda and Haydn T. Kissick.
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