Jussi Nikkola: How to determine Urothelial Cancer with High-volume Urine DNA Analysis
Jussi Nikkola, Clinical Researcher at Tampere University, shared a post on X:
“Excited to share our urine tumor DNA assay UroScout results published today in European Urology.
– 497 urine DNA samples from 281 patients
-100% sens for ≥T1 bladder cancer
– 94% sens for Ta bladder cancer
– 92% sens for any grade UTUC
– 100% sens for MI/HG-UTUC
– 90% sens for recurrence detection
– Identification of Lynch syndrome
– Three-tier diagnostic workflow for cystoscopy
– pre-screening Potential to replace ~80% of diagnostic cystoscopies
– 2 utDNA mutations, AF≥5%
– PPV 100%
– 69% of UC patients could be scheduled directly for OR procedures.
Check supplementaries for more results”
Sensitive Detection of Urothelial Cancer via High-volume Urine DNA Analysis
Authors: Jussi Nikkola, Lauri Ryyppö, Juuso Vuorinen, Heini Kallio, Hanna Selin, Pyry Jämsä, Jonne Åkerla, Tuomo Virtanen, Tarmo Pekkarinen, Antti Kaipia, Johanna Pulkkinen, Gillian Vandekerkhove, David C. Müller, Alexander W. Wyatt, Peter C. Black, Matti Nykter, Thea Veitonmäki and Matti Annala.
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