News Feed Opinion Blog Career Insight Dialogues Celebrities Oncolibrary
Positive Societies Drugs Stories History Cancer Center Near Me Cancer Types Immune Oncology Oncologist Near Me
May, 2025
May 2025
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  
Understanding Double-Strand Breaks in the Formation of ecDNA
Oct 17, 2024, 17:41

Understanding Double-Strand Breaks in the Formation of ecDNA

Steven Artandi, Director of Stanford Cancer Institute and Professor at Stanford University School of Medicine, shared a recent article by John C. Rose on X:

“SCI members Howard Chang, Paul Mischel, and others found support a model of ecDNA formation in which double strand break ends dissociate from their legitimate ligation partners prior to joining of illegitimate ends to form the ecDNA and excision scar.

Title: Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair.

Authors: John C. Rose, Julia A. Belk, Ivy Tsz-Lo. Wong, Jens Luebeck, Hudson T. Horn, Bence Daniel, Matthew G. Jones, Kathryn E. Yost, King L. Hung, Kevin S. Kolahi, Ellis J. Curtis, Calvin J. Kuo, Vineet Bafna, Paul S. Mischel and Howard Y. Chang

ecDNA

ecDNA

 

cancer DNA biogenesis ecDNA formation genomic DNA repair Howard Y. Chang Hudson T. Horn Ivy Tsz-Lo. Wong Jens Luebeck John C. Rose Julia A. Belk OncoDaily Oncology Paul S. Mischel Stanford University School of Medicine Steven Artandi Vineet Bafna
Special Coverage
Blog
May 9, 2025, 19:44
Amanda Impellizzeri: MCED Act Just Hit a Historic Milestone
Blog
May 9, 2025, 19:25
Sondus Alsharidah: Building Bridges in Pediatric Oncology and Oncology Care
Blog
May 9, 2025, 19:03
Rasha Aboelhassan: Have you ever felt like everything is going so smoothly, and your dreams are coming true?
Blog
May 9, 2025, 18:51
Emma Walmsley: GSK Medics Are Accelerating the Partnerships We Need
Insight
May 9, 2025, 18:09
Katsuaki Maehara Highlights TIM-3 as a Potential Target for Lung Adenocarcinoma Precancer Interception
Societies
May 9, 2025, 18:03
Who From Oncology is Featured in TIME100 Health 2025?
Blog
May 9, 2025, 17:53
Jill Barnholtz-Sloan: It Takes Everyone on the Team to Fulfill the Mission of the NCI to End Cancer
Blog
May 9, 2025, 17:45
AstraZeneca Unveils $300M Cell Therapy Facility in Rockville to Boost CAR-T Cell Therapy Production
Blog
May 9, 2025, 17:38
Matthew Mifsud Highlights USF ENT and TGH Cancer Institute 2025 Head and Neck Cancer Symposium
Blog
May 9, 2025, 17:23
Jan-Henning Klusmann: RNA Innovation in Focus – Retreat of the DFG Research Unit RU5433
Insight
May 9, 2025, 17:19
Bishal Gyawali: I Hope Trial Sponsors and Trialists Will Find These Results Helpful and Meaningful
Science
May 9, 2025, 16:45
Asaf Maoz: Have You Seen Non-Response to Immunotherapy in Locally Advanced dMMR/MSI-H Rectal Cancer?