Insight

Oct 17, 2024, 17:41

Understanding Double-Strand Breaks in the Formation of ecDNA

Steven Artandi, Director of Stanford Cancer Institute and Professor at Stanford University School of Medicine, shared a recent article by John C. Rose on X:

“SCI members Howard Chang, Paul Mischel, and others found support a model of ecDNA formation in which double strand break ends dissociate from their legitimate ligation partners prior to joining of illegitimate ends to form the ecDNA and excision scar.

Title: Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair.

Authors: John C. Rose, Julia A. Belk, Ivy Tsz-Lo. Wong, Jens Luebeck, Hudson T. Horn, Bence Daniel, Matthew G. Jones, Kathryn E. Yost, King L. Hung, Kevin S. Kolahi, Ellis J. Curtis, Calvin J. Kuo, Vineet Bafna, Paul S. Mischel and Howard Y. Chang

ecDNA

cancer DNA biogenesis ecDNA formation genomic DNA repair Howard Y. Chang Hudson T. Horn Ivy Tsz-Lo. Wong Jens Luebeck John C. Rose Julia A. Belk OncoDaily Oncology Paul S. Mischel Stanford University School of Medicine Steven Artandi Vineet Bafna

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