Intrinsic temperature increases ferroptosis evasion and chemotherapy resistance in Pancreatic Cancer, suggested by Anirban Maitra

Anirban Maitra shared a post on X:

“Fascinating!

Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in Pancreatic Cancer. Pancreatic cancers have a higher “ambient” temperature than the surrounding uninvolved pancreas.

What are the metabolic consequences of this observation?”

Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer

Authors: Vincent de Laat, Halit Topal, Xander Spotbeen, Ali Talebi, Jonas Dehairs, Jakub Idkowiak, Frank Vanderhoydonc, Tessa Ostyn, Peihua Zhao, Maarten Jacquemyn, Michele Wölk, Anna Sablina, Koen Augustyns, Tom Vanden Berghe, Tania Roskams, Dirk Daelemans, Maria Fedorova, Baki Topal and  Johannes V. Swinnen.

Source: Anirban Maitra/X

Dr. Anirban Maitra serves as Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center since August 2013, and directs the Sheikh Ahmed Pancreatic Cancer Research Center. He leads an NCI-funded laboratory dedicated to pancreatic cancer research, focusing on genetics and molecular pathology in human and mouse models. His research aims to advance early detection and interception strategies to enhance patient survival rates in pancreatic cancer.