Gustavo Viani: Neoadjuvant immunotherapy for unresectable stage III NSCLC followed by CRT

Gustavo Viani shared a post on LinkedIn about a recent paper by Helen Ross et al. published in JAMA Oncology.

“Atezolizumab Before and After Chemoradiation for Unresectable Stage III Non–Small Cell Lung Cancer A Phase II Nonrandomized Controlled Trial”

Authors: Helen Ross, David Kozono,  Xiaofei Wang, Everett Vokes, Thomas Stinchcombe et al.

“Good results with neoadjuvant immunotherapy for unresectable stage III NSCLC followed by CRT! Randomized clinical trials are needed!

Study Design: Phase II, single-cohort trial with 62  with unresectable stage III NSCLC.

• Intervention: Atezolizumab given before and after chemoradiation therapy (CRT)
• Outcome:  Disease control rate at 12 weeks was 74.2%

Results:

• Median PFS 30 m / OS at 24 months 73.7%
• Adverse Events:27.4% grade 3+ immune-related events, including pneumonitis and Guillain-Barré syndrome.”

Source: Gustavo Viani/LinkedIn

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Gustavo Viani, MD is an Associate Professor in the Department of Medical Imaging, Hematology, and Oncology at Hospital das Clínicas, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP-USP). Dr. Viani’s research focuses on radiation oncology, with expertise in brachytherapy, stereotactic radiosurgery, dose fractionation, radiation tolerance, and overall oncology practices.