Extrachromosomal DNA role in cancer progression suggested by Jean-Charles Soria

Jean-Charles Soria shared a post on X:

“Recent research highlights extrachromosomal DNA role in cancer progression.

By increasing oncogene copy numbers, enhancing transcription via ‘ecDNA hubs,’ & promoting genetic diversity, ecDNA drives rapid tumor evolution & treatment resistance.”

Extrachromosomal DNA in cancer

Authors: Xiaowei Yan, Paul Mischel and Howard Chang.

Source: Jean-Charles Soria/X

Jean-Charles Soria serves as Amgen’s senior vice president of Oncology within Global Development. He is a medical oncologist and a professor of medicine at Paris-Saclay University. From 2017 to 2019, he was the senior vice president of Research and Development in Oncology at AstraZeneca. Additionally, Soria has authored or co-authored over 670 articles in leading international journals and has been recognized as one of the world’s most influential research scientists.