Myeloma Paper of the Day, September 22nd, suggested by Robert Orlowski
Robert Orlowski shared on X:
“Myeloma Paper of the Day: Optical genome mapping in conjunction with FISH, karyotyping and NGS detects MYC rearrangements in 43.3% of patients, and MYC protein over-expression in 72.7% of these cases, especially with translocations involving Ig loci.”
Source: Robert Orlowski/X
Characterization of MYC Rearrangements in Multiple Myeloma: an Optical Genome Mapping Approach
Authors: Jung Yoon, Taesung Jeon, Jung-Ah Kwon and Soo-Young Yoon.
Other posts featuring Robert Orlowski on OncoDaily.
Robert Orlowski, M.D., Ph.D., holds multiple positions at The University of Texas, MD Anderson Cancer Center including Chairman, Ad Interim Director of Myeloma, and Professor of Medicine in the Departments of Lymphoma/Myeloma and Experimental Therapeutics within the Division of Cancer Medicine. Additionally, he chairs the SWOG Barlogie/Salmon Myeloma Committee, which is part of the National Clinical Trials Network, dedicated to advancing new therapies and understanding the biology of myeloma.
Dr. Orlowski’s expertise lies in both clinical practice and scientific research, with a particular focus on translating laboratory discoveries into effective treatments for patients. He investigates drug resistance mechanisms in myeloma and seeks to identify predictive biomarkers for treatment response. Notably, his past contributions include leadership roles in developing proteasome inhibitors like bortezomib and carfilzomib, as well as monoclonal antibodies such as daratumumab and elotuzumab.
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