Angela Mastronuzzi: Extremely important research on high-grade gliomas

Angela Mastronuzzi shared a post on LinkedIn:

“Very proud to present our published work and be a part of this extremely important research on high-grade gliomas, just out with Cancer Cell of Cell Press!

“GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant”

Highlights
– DHG-H3G34 follows a hierarchy along the interneuron lineage development continuum
– DHG-H3G34 tumor cells mirror spatial nests of normal human interneuron development
– Interneuron lineage progenitor states present a distinct vulnerability
– CDK6 is a promising clinically actionable target in DHG-H3G34.”

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

Authors: Ilon Liu et al.

Source: Angela Mastronuzzi/LinkedIn

Angela Mastronuzzi is pediatric hematologist-oncologist and the Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital (Italy). She is also a professor at the UniCamillus International Medical University, and a Board Member of AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica). Her main fields of interest are CNS tumors and innovative therapies.