Genetic interactions that shape tumorigenesis

Vincent Lam, medical oncologist at Johns Hopkins Kimmel Cancer Center, shared a post by Monte Winslow’s Lab, on X:

“Cool stuff from Monte Winslow’s Lab further suggesting that variant 3 is more oncogenic; perhaps other ‘short’ EML4-ALK fusions too.
Also, tumor suppressors have variant-specific impact.
On the road towards personalizing ALK therapy…”

Quoting for Monte Winslow’s Lab post:

“Amazing collaboration between  Emily Shuldiner and Alberto Diaz using somatic genome editing to model 60 different genotypes of EML4-ALK lung cancer. Genetics say that Variant 1 and Variant 3 should be considered distinct oncogenes.

EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

Authors: Alberto Diaz-Jimenez, Emily G. Shuldiner, Kalman Somogyi, Oscar Gonzalez, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors, Smruthy Sivakumar, Saumya D. Sisoudiya, Ethan S. Sokol, Dmitri A. Petrov, Monte M. Winslow, Rocio Sotillo.”

Source: Vincent Lam/X and Monte Winslow’s Lab/X