Sendurai Mani: An interesting study linking thyroid function and brain activity
Sendurai Mani shared a post on LinkedIn:
“In this study, Hochbaum and team uncovered the direct impact of thyroid hormone on the adult male mouse brain’s frontal cortex. Their research reveals that aside from its role in metabolism regulation, thyroid hormone triggers the activation of specific genes crucial for influencing neuron connections, synapses, and myelination.
These genetic changes ultimately drive significant alterations in brain circuits. Moreover, this study highlights the hormone’s pivotal role in the frontal cortex, where it not only governs innate exploratory behaviors but also plays a causal role in promoting exploratory decision-making. An interesting study linking thyroid function and brain activity.”
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration
Authors: Daniel R. Hochbaum et al.
Sendurai A. Mani is an Indian-American oncologist and molecular biologist. Currently holding the Dean’s Chair for Translational Oncology at Brown University Warren Alpert Medical School, Dr. Mani also serves as the Associate Director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School.
Dr. Mani’s research focuses on finding the mechanisms driving cancer metastasis and therapy resistance, particularly in breast cancer. He is renowned for his discovery of cancer stem cells and their role in tumor progression and treatment resistance.
Source: Sendurai Mani/LinkedIn