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Understanding Gleason system evolution for accurate prostrate diagnosis and treatment, summary by María Natalia Gandur Quiroga

María Natalia Gandur Quiroga/X

Aug 28, 2024, 18:15

Understanding Gleason system evolution for accurate prostrate diagnosis and treatment, summary by María Natalia Gandur Quiroga

María Natalia Gandur Quiroga shared a recent article by Alessandro Crestani on X, adding:

“Gleason system evolution: Fundamental for accurate prostate cancer diagnosis and prognosis, Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran Carmine Franzese, Gianluca Giannarini, Alessandro Crestani, and Eamonn T. Rogers Rodolfo Montironi.

Grade Groups (GGs): Developed from Gleason scores, they help personalize treatment plans.

GG1: Despite a favorable prognosis (e.g., no lymph node metastases in over 14,000 cases), it remains classified as cancer due to invasive characteristics and molecular similarities with higher grades.

Cribriform patterns and intraductal carcinoma (IDC-P): Strongly linked to poorer outcomes, aggressive behavior, and should be carefully considered in treatment decisions.

Molecular testing: Increasingly important, distinguishing GG4 and GG5 tumors, aiding in risk stratification and tailored therapies. Prognostic heterogeneity within GG4 and GG5: Highlights the need for nuanced grading to guide clinical decisions accurately.

Takeaway: Direct interaction with patients is crucial, helping them understand pathology reports and encouraging informed discussions with their healthcare providers.”

Patients ask and pathologists answer: ten questions around prostate cancer grading

Authors: Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran, Carmine Franzese, Gianluca Giannarini, Alessandro Crestani, Eamonn T. Rogers, and Rodolfo Montironi.

Source:María Natalia Gandur Quiroga/X

Maria Natalia Gandur Quiroga is a Medical Oncologist and Chief of the Division of Genitourinary Medical Oncology at the Ángel H. Roffo Oncology Institute in Buenos Aires, Argentina. She is a Professor of Medicine at the University of Buenos Aires at the Oncologists Post Graduates Studies. Her research focuses on clinical trials with aims to improve the treatment of patients with urologic tumors. She is an active member of the European Association for Cancer Research, Argentinian Medical Association and American Society of Clinical Oncology.

Alessandro Crestani Alessia Cimadamore Antonio Lopez-Beltran Antonio Lopez-Beltran Carmine Franzese cancer Carmine Franzese Eamonn T. Rogers Eamonn T. Rogers Rodolfo Montironi Gianluca Giannarini Liang Cheng lymph María Natalia Gandur Quiroga OncoDaily Oncology prostate cancer Rodolfo Montironi

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