Gustavo Viani summarising the RAPIDO trial

Gustavo Viani, Professor of Radiation Oncology at Ribeirão Preto Medical School, University of Sao Paulo, recently posted on X:

“ 2 CTH cycles less do not compromise the results with an increase CR-R:RAPIDO trial!

Methods: 

• high-risk locally advanced rectal cancer (LARC).
• Study design: Prospective observational cohort study.
• Treatment: Short-course leading to 4 CAPOX or 6 FOLFOX leading to mesorectal excision or watch-and-wait (W and W) for clinical complete response (cCR).
• Complete response (CR), locoregional recurrences, neurotoxicity.

Outcomes:

• CR rate: RAPIDO trial (24%).
• LRR: decreased (around 5-6%).
• Neurotoxicity: less than RAPIDO trial.”

Source: Gustavo Viani/X

Total neoadjuvant treatment using short-course radiotherapy and four CAPOX cycles in locally advanced rectal cancer with high-risk criteria for recurrence: a Swedish nationwide cohort study (LARCT-US).

Authors: Bengt Glimelius, Tanweer Khan, Karin Adolfsson, Eva Angenete, Åke Berglund, Kristina Bonde, Nils Elander, Tone Fokstuen, Johan Haux, Israa Imam, Cecilia Lagerbäck, Ingrid Ljuslinder, Andrzej Piwowar, Marie Zajicova, and Per J. Nilsson.