Rahul Banerjee: A ‘CAR-E’ molecule that gives – basically a care package for CAR T-cells as they start their first jobs

Rahul Banerjee, Assistant Professor at UW Medicine, shared a posts by Mohammad Rashidian, Assistant Professor, Dana-Farber Cancer Institute, on X:

“How do you get BCMA CAR T cells in Multiple Myeloma to stick around without overstimulating T cells systemically?

A ‘CAR-E’ molecule that gives only them a lil’ boost of IL-2. Basically a care package for CAR T-cells as they start their first jobs.”

Quoting Mohammad Rashidian‘s post:

“Excited to share our paper in Nature Biotechnology. We’ve developed a CAR-Enhancer (CAR-E) that enhances the activity and persistence of CAR T-cells. These memory CAR T-cells can re-expand months later.

‘A CAR enhancer increases the activity and persistence of CAR T cells‘

Authors: Taha Rakhshandehroo, Shreya R. Mantri, Heydar Moravej, Benjamin B. V. Louis, Ali Salehi Farid, Leila Munaretto, Kathryn Regan, Radia M. M. Khan, Alexandra Wolff, Zoe Farkash, Min Cong, Adrien Kuhnast, Ali Nili, Uk-Jae Lee, Harris H. Allen, Lea Berland, Ester Simkova, Safak C. Uslu, Soheil Tavakolpour, Jennifer E. Rowley, Elisabeth Codet, Haneyeh Shahbazian, Jessika Baral, Jason Pyrdol, Caron A. Jacobson, Omar Nadeem, Hadi T. Nia, Kai W. Wucherpfennig, Mohammad Rashidian.”

Source: Rahul Banerjee/X and Mohammad Rashidian/X