![What comes after sotorasib and adagrasib?](https://oncodaily.com/pub/uploads/2024/07/41571_2021_545_Figa_HTML-1.png)
Jul 12, 2024, 11:24
What comes after sotorasib and adagrasib?
Aakash Desai, Thoracic/Phase 1 Oncologist at UAB O’Neal Comprehensive Cancer Center, shared a post on X about a recent paper titled “The next-generation KRAS inhibitors…What comes after sotorasib and adagrasib?” published in Lung Cancer Journal.
Authors: Yuko Oya, Kazuyoshi Imaizumi, Tetsuya Mitsudomi. .
“KRAS, once ‘undruggable,’ now sotorasib and adagrasib, but efficacy is limited.
Next-gen KRAS G12C/non-G12Ci and innovative approaches like molecular shielding and protein degradation are on the horizon!
Combos with SHP2/SOS1 inhibitors, chemo, or immune checkpoint inhibitors are being explored to tackle resistance.
Great review in Lung Cancer Journal.”
Source: Aakash Desai/X