Horizon Europe Mission Cancer: CANCER-03 Pragmatic Clinical Trials for Refractory Cancers

Horizon Europe Mission Cancer: CANCER-03 Pragmatic Clinical Trials for Refractory Cancers

Due Date: 09/15/2026

This Mission Cancer topic supports pragmatic clinical trials aimed at improving immunotherapeutic interventions for patients with refractory cancers, focusing on effectiveness in real-world settings and evidence directly applicable to practice. The call text emphasizes randomised or cluster-randomised, academic investigator-initiated pragmatic trials that benefit patients with refractory cancers across stages, subtypes, age groups, and societal contexts. Endpoints should include overall survival and patient-reported outcomes/quality of life defined together with patients and caregivers/families.

Eligibility Criteria:

  • Must submit an eligible proposal under this RIA topic and comply with Horizon Europe call conditions (see Work
  • Programme and the Funding & Tenders Portal topic page).
  • Proposal should include randomised or cluster-randomised academic investigator-initiated pragmatic clinical trials for patients with refractory cancers.
  • Trial endpoints should target overall survival and patient-reported outcomes/quality of life important to patients and caregivers/families.

Funding Details: 

  • Action type: RIA.
  • Total topic budget: €22.19M.
  • Expected EU contribution per project: €7.00M–€8.00M.
  • Indicative number of projects funded: 3.

Deadline:

  • Deadline(s): 15 Sep 2026.

Where to go for further information: