The National Cancer Institute (NCI) Mechanisms that Impact Cancer Risk after Bariatric Surgery R01 Grant supports investigator-initiated research exploring the biological mechanisms through which bariatric surgery may alter cancer risk.
Projects may investigate changes in areas such as bile acids, gut microbiome, metabolic pathways, immune signaling, or other surgery-related mechanisms that could influence cancer development. Researchers can request up to $500,000 in direct costs per year for up to five years, with the next new-application deadline on October 5, 2026.
Eligibility Criteria
- Eligible applicants include public and private institutions of higher education.
- Nonprofit organizations with or without 501(c)(3) status may apply.
- Foreign/non-U.S. organizations are not eligible to apply.
- Foreign components of eligible U.S. organizations are permitted under NIH policy.
- Multiple PD/PI applications are permitted where appropriate.
- Applicant organizations may submit more than one scientifically distinct application.
- Cost sharing or matching funds are not required.
Funding Details
- Maximum direct costs: $500,000 per year.
- Maximum project duration: 5 years.
- Grant mechanism: NIH R01 Research Project Grant.
Deadline
- Next new application deadline: October 5, 2026.
- Resubmission/revision deadline: November 5, 2026.
- Applications are due by 5:00 PM local time of the applicant organization.
- Earliest project start: July 2027.
- NOFO expiration date: January 8, 2028.
Further Information
- Research must focus on mechanisms linking bariatric surgery to cancer risk, rather than short-term outcomes such as weight loss or diabetes control.
- Projects focused entirely on in vitro studies are not eligible.
- NCI strongly encourages clinical-trial applicants to contact program staff well before submission to confirm fit.
- All applications generating scientific data must include a Data Management and Sharing Plan.
- Applications are submitted through NIH ASSIST, Grants.gov Workspace, or an approved institutional system-to-system solution.
- Official program page: View the NIH NOFO