Research Project Grant (R01)
The NIH R01 grant supports discrete, specified research projects led by the named investigator(s), reflecting their specific expertise and interests. The R01 is NIH’s flagship funding mechanism for independent research projects across the biomedical and behavioral sciences.
Special Considerations:
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Early Stage Investigators (ESI): Applications with all PD/PIs holding ESI status receive special review consideration.
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Katz ESI Change-in-Direction Grant: Supports innovative projects by ESIs without preliminary data.
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Continuous Submission Policy: Available for PD/PIs serving on NIH review panels or advisory committees, allowing rolling submissions.
Award Information:
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Instrument: Grant
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Category: Research and Development
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Mechanism Code: RP – Research Projects
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Budget & Duration:
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Generally unlimited within project needs (check specific FOA).
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Modular budget for domestic applicants (direct costs in $25K modules).
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Project periods: 1–5 years, renewable via competing renewal.
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Allowable Costs:
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PI and key personnel salaries & fringes
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Equipment, supplies, consultant fees
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Alterations/renovations
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Publication, travel, contract & consortium costs
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Facilities & Administrative (indirect) costs
Application & Submission:
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Parent FOAs: Use R01 Parent Announcements; verify participating ICs.
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Forms & Guide: Follow the NIH SF424 (R&R) instructions and “How to Apply” guide.
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Due Dates: Standard dates apply (February 5, June 5, October 5 for new submissions).
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Submission Portal: Grants.gov → eRA Commons.
Resources & Contacts:
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FOA Lookup: NIH Guide for Grants & Contracts
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Program Staff: See Section VII of the FOA for scientific/research contacts.
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Admin Support: Institutional grants office; NIH eRA Help Desk.
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