Drugs

Jul 9, 2025, 15:28

Rahul Banerjee: Early Daratumumab Effective for NDMM with Severe Cast Nephropathy

Rahul Banerjee, Assistant Professor at Fred Hutchinson Cancer Center at the University of Washington, shared a post on X:

“Nice myeloma work in Blood Advances by Kim, NoopurRaje, Andrew Yee et al.

For NDMM plus severe cast nephropathy (e.g., peri-dialysis), rapid dara initiation works quite well. Inpatient dara is expensive, but I’d argue PLEX even more expensive plus more burdensome for patient!

Andrew Yee, I must say I love this visual abstract: small grayer-looking kidneys must mean some degree of cast nephropathy!

Lest you think we MM doctors always say more is better… in JCO ASCO

RCT of CyBorD vs Vd (e.g., Cy 750 mg/m2 per cycle), no benefit to adding Cy on top of Velcade.

[P.S. This is one scenario where I do think 2x weekly Velcade reasonable!].”

Rahul Banerjee

Title: Early daratumumab therapy improves renal outcomes in newly diagnosed patients with myeloma admitted with kidney injury

Authors: E. Bridget Kim, Jack E. Malespini, Matthew Lei, Samuel S. Han, Cole W. Minsky, Andrew R. Branagan, Elizabeth K. O’Donnell, Diana Cirstea, Noopur S. Raje, Andrew J. Yee

Journal: Blood Advances

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Rahul Banerjee: Early Daratumumab Effective for NDMM with Severe Cast Nephropathy

Title: Randomized Trial Comparing Double Versus Triple Bortezomib-Based Regimen in Patients With Multiple Myeloma and Acute Kidney Injury Due to Cast Nephropathy

Authors: Frank Bridoux, Bertrand Arnulf, Lionel Karlin, Nicolas Blin, Nolwenn Rabot, Margaret Macro, Vincent Audard, Karim Belhadj, Brigitte Pegourie, Pierre Gobert, Emilie Cornec Le Gall, Bertrand Joly, Alexandre Karras, Arnaud Jaccard, Karine Augeul-Meunier, Salomon Manier, Bruno Royer, Denis Caillot, Mourad Tiab, Sébastien Delbes, Felipe Suarez, Cécile Vigneau, Sophie Caillard, Nina Arakelyan-Laboure, Damien Roos-Weil, Sylvie Chevret, Jean Paul Fermand

Journal: JCO ASCO

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Rahul Banerjee: Early Daratumumab Effective for NDMM with Severe Cast Nephropathy

More posts featuring Rahul Banerjee.

Alexandre Karras Andrew J Yee Andrew R. Branagan Arnaud Jaccard Bertrand Arnulf Bertrand Joly Brigitte Pegourie Bruno Royer cancer Cécile Vigneau Cole W. Minsky Damien Roos-Weil Denis Caillot Diana Cirstea E. Bridget Kim Elizabeth K. O'Donnell Emilie Cornec Le Gall Felipe Suarez Frank Bridoux Jack E. Malespini Jean Paul Fermand Karim Belhadj Karine Augeul-Meunier Lionel Karlin Margaret Macro Matthew Lei Mourad Tiab multiple myeloma Nicolas Blin Nina Arakelyan-Laboure Nolwenn Rabot Noopur S. Raje OncoDaily Oncology Pierre Gobert Rahul Banerjee Salomon Manier Samuel S. Han Sébastien Delbes Sophie Caillard Sylvie Chevret Vincent Audard

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