Rahul Banerjee: Early Daratumumab Effective for NDMM with Severe Cast Nephropathy
Rahul Banerjee, Assistant Professor at Fred Hutchinson Cancer Center at the University of Washington, shared a post on X:
“Nice myeloma work in Blood Advances by Kim, NoopurRaje, Andrew Yee et al.
For NDMM plus severe cast nephropathy (e.g., peri-dialysis), rapid dara initiation works quite well. Inpatient dara is expensive, but I’d argue PLEX even more expensive plus more burdensome for patient!
Andrew Yee, I must say I love this visual abstract: small grayer-looking kidneys must mean some degree of cast nephropathy!
Lest you think we MM doctors always say more is better… in JCO ASCO
RCT of CyBorD vs Vd (e.g., Cy 750 mg/m2 per cycle), no benefit to adding Cy on top of Velcade.
[P.S. This is one scenario where I do think 2x weekly Velcade reasonable!].”
Title: Early daratumumab therapy improves renal outcomes in newly diagnosed patients with myeloma admitted with kidney injury
Authors: E. Bridget Kim, Jack E. Malespini, Matthew Lei, Samuel S. Han, Cole W. Minsky, Andrew R. Branagan, Elizabeth K. O’Donnell, Diana Cirstea, Noopur S. Raje, Andrew J. Yee
Journal: Blood Advances
Title: Randomized Trial Comparing Double Versus Triple Bortezomib-Based Regimen in Patients With Multiple Myeloma and Acute Kidney Injury Due to Cast Nephropathy
Authors: Frank Bridoux, Bertrand Arnulf, Lionel Karlin, Nicolas Blin, Nolwenn Rabot, Margaret Macro, Vincent Audard, Karim Belhadj, Brigitte Pegourie, Pierre Gobert, Emilie Cornec Le Gall, Bertrand Joly, Alexandre Karras, Arnaud Jaccard, Karine Augeul-Meunier, Salomon Manier, Bruno Royer, Denis Caillot, Mourad Tiab, Sébastien Delbes, Felipe Suarez, Cécile Vigneau, Sophie Caillard, Nina Arakelyan-Laboure, Damien Roos-Weil, Sylvie Chevret, Jean Paul Fermand
Journal: JCO ASCO
More posts featuring Rahul Banerjee.
-
Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023