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Erman Akkus: NSCLC and anti-EGFR treatments from the ASCO Educational Book
Photo from Erman Akkus/X
Apr 4, 2024, 13:34

Erman Akkus: NSCLC and anti-EGFR treatments from the ASCO Educational Book

Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X/Twitter:

“NSCLC and anti-EGFR treatments from the ASCO Educational Book

  • Early stage-adjuvant
  • Gefitinib, icotinib > high DFS, no OS benefit (ADJUVANT/CTONG 1104, IMPACT and EVIDENCE)
  • Osimertinib > high DFS, OS (ADAURA)
  • Ongoing trials: ADAURA2, TARGET
  • Ongoing trial in neoadjuvant: NeoADAURA
    +  Anti-ALK, IO for driver mutation
  • Unresectable, after defitive treatment
  • Osimertinib> high PFS (LAURA, ongoing)
  • Ongoing trials: PACIFIC4, HORIZON-01
  • Metastatic
  • 1G, 2G and new TKIs (in figures below)
  • Resistance mechanisms and strategies to overcome (in figures below).”

Erman Akkus: NSCLC and anti-EGFR treatments from the ASCO Educational Book

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Source: Erman Akkus/X

ADAURA ADAURA2 ADJUVANT/CTONG 1104 Ankara University anti-EGFR treatments ASCO ASCO Educational Book cancer Erman Akkus EVIDENCE Gefitinib HORIZON-01 icotinib impact NeoADAURA non small cell lung cancer NSCLC OncoDaily Oncology osimertinib PACIFIC4 TARGET TKIs
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