Maryam Lustberg: Trametinib with or without Uprosertib in Metastatic TNBC
Maryam Lustberg, The Director of the Center for Breast Cancer at Smilow Cancer Hospital, shared a post on LinkedIn:
“Highlighting important work from my colleagues and past mentors and remembering Bhuvana Ramaswamy.
In patients with mTNBC, Trametinib monotherapy demonstrated limited efficacy and addition of Uprosertib was associated with numerically greater objective responses but no difference in PFS. Translational analyses suggest ctDNA clearance as a potential early biomarker of response.”
Authors: Vishnu Prasath, Hinda Boutrid, Robert Wesolowski, Mahmoud Abdel-Rasoul, Cynthia Timmers, Maryam Lustberg, Rachel M. Layman, Erin Macrae, Ewa Mrozek, Charles Shapiro, Kristyn Glover, Mark Vater, G. Thomas Budd, Lyndsay Harris, Claudine Isaacs, Claire Dees, Charles M. Perou, Gary L. Johnson, Andrew Poklepovic, Helen Chen, Miguel Villalona-Calero, William Carson, Daniel G. Stover, Bhuvaneswari Ramaswamy
Dr. Maryam Lustberg is the Director of the Center for Breast Cancer at Smilow Cancer Hospital and Yale Cancer Center, and Chief of Breast Medical Oncology at Yale Cancer Center. She is also an Associate Professor of Medicine (Medical Oncology). She has been recognized for her patient-focused care with awards that include being rated by Forbes as one of the top breast medical oncologists in the nation and named to the Castle Connolly list of “Regional Top Doctors,” and “Exceptional Women in Medicine” for 2020.
Dr. Lustberg is a member of the ASCO Annual Meeting Education Committee, Patient and Survivor Care Education Committee, and Neuropathy Expert Guideline Panel. She is the immediate past President for the International Organization Multinational Association of Supportive Care in Cancer (MASCC). She serves as an Associate Editor for the Journal of Cancer Survivorship.
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