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Raffaele Colombo: Here the breakdown of the Monomethyl auristatin E Antibody Drug Conjugates
Photo from Raffaele Colombo/X
Nov 4, 2023, 00:58

Raffaele Colombo: Here the breakdown of the Monomethyl auristatin E Antibody Drug Conjugates

Raffaele Colombo, Principal Scientist at Zymeworks, shared on X/Twitter:

106 auristatin Antibody Drug Conjugates (ADCs) have reached clinic development, of which two-thirds (= 71 ADC) with Monomethyl auristatin E (MMAE) as payload! Here the breakdown of the MMAE ADCs:  

  • 4 approved by FDA
  •  1 approved by the National Medical Products Administration in China
  • 41 in clinical development  
  • 25 discontinued

The MMAE history:

Image

Source: Raffaele Colombo/Twitter

cancer FDA National Medical Products Administration OncoDaily Oncology Raffaele Colombo Zymeworks
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