Thomas Powles is a Professor of Genitourinary Oncology and Director of Barts Cancer Centre at St Bartholomew’s Hospital, and Lead for Solid Tumour Research at Barts Cancer Institute, London. He is an international leader in the treatment of urinary cancers, with a research focus spanning phase I to phase III clinical trials, particularly translational studies of targeted and immune therapies.
Professor Powles has played a central role in advancing front-line combination therapies in renal cell carcinoma and immune checkpoint inhibition in bladder cancer, contributing to multiple EMA and FDA drug approvals and shaping modern standards of care. He is Editor-in-Chief of Annals of Oncology, co-leads European clinical guidelines for genitourinary cancers, and is famously recognized for his latest research that transformed the standards of bladder cancer treatment with antibody drug conjugates. He has been recognized in Nature’s top ten people who shaped science in 2023.
The 100 Most Influential People in Oncology in 2025 recognizes the changemakers in cancer care who have helped shape current practice in oncology and continue to drive innovation and research towards better outcomes, advocacy, philanthropy, leadership and education. For the many deserving individuals not mentioned in this list, we will continue to acknowledge, honor and elevate your voices in our daily publications from across the world.
See the full list of The 100 Influential People in Oncology in 2025 and stay tuned for the results of special category nominations to be announced.
