Michael Sapienza is Chief Executive Officer of the Colorectal Cancer Alliance, the largest colon and rectal cancer advocacy organization in the U.S. He founded The Chris4Life Colon Cancer Foundation and led its 2016 merger with the Colon Cancer Alliance, creating a unified national nonprofit. Michael spearheads Project Cure CRC, driving the Alliance’s $100 million commitment to innovative colorectal cancer research and improving patient outcomes through initiatives such as BlueHQ.org.
He has led high-profile awareness campaigns, including the “Lead From Behind” partnership with Ryan Reynolds, and serves on the Ruesch Center Advisory Board at Georgetown University, the President’s Cancer Panel, and NCCRT Steering Committee. Recognized nationally, he has received the David Jagelman Award, the Public Service Award from the Society for Surgery of the Alimentary Tract, the Champion Award from Preventing Colorectal Cancer.
The 100 CEOs featured here reflect the diversity and complexity of modern oncology leadership. In 2025, some lead the world’s largest cancer institutions; others guide specialized societies or emerging innovators. What unites them is responsibility: for millions of patients, for the integrity of science, and for the future direction of cancer care globally.
This list is not a celebration of power, but a recognition of stewardship, accountability, and impact – and of the leaders whose choices continue to shape the fight against cancer. For the many deserving individuals not mentioned in this list, we will continue to acknowledge, honor and elevate your voices in our daily publications from across the world.
See the full list of The 100 Influential CEOs in Oncology in 2025 and stay tuned for other special category nominations
