Larry Norton is internationally recognized for pioneering the application of mathematical oncology to cancer treatment, including co-inventing the Norton–Simon Model and developing dose-dense chemotherapy, which transformed breast cancer therapy worldwide. He is Senior Vice President at Memorial Sloan Kettering Cancer Center, Founding Medical Director of the Evelyn H. Lauder Breast Center, and the Norna S. Sarofim Chair in Clinical Oncology. He is also Professor of Medicine at Weill Cornell Medical College and Founding Scientific Director of the Breast Cancer Research Foundation (BCRF), which he has led since its inception in 1993.
He has played a central leadership role in global oncology, serving as President of the American Society of Clinical Oncology (ASCO), Chair of the ASCO Foundation (now Conquer Cancer), and as a U.S. Presidential appointee to the National Cancer Advisory Board. Dr Norton’s research has contributed to the development of key agents such as paclitaxel and trastuzumab, and to foundational concepts in cancer metastasis, including tumor self-seeding. Dr. Norton has received numerous honors, including ASCO’s David A. Karnofsky Memorial Award and election to the American Academy of Arts & Sciences.
The 100 Most Influential People in Oncology in 2025 recognizes the changemakers in cancer care who have helped shape current practice in oncology and continue to drive innovation and research towards better outcomes, advocacy, philanthropy, leadership and education. For the many deserving individuals not mentioned in this list, we will continue to acknowledge, honor and elevate your voices in our daily publications from across the world.
See the full list of The 100 Influential People in Oncology in 2025 and stay tuned for the results of special category nominations to be announced.
