Fabrice Barlesi is General Director of Gustave Roussy, one of Europe’s leading comprehensive cancer centers, where he leads the institution’s clinical, scientific, and strategic development. Under his leadership, Gustave Roussy has reinforced its position as a European and global reference centre for precision oncology, immunotherapy, and early-phase clinical research, while strengthening integration between laboratory discovery, translational science, and high-complexity cancer care. His tenure has focused on sustaining Gustave Roussy’s leadership in first-in-human trials, biomarker-driven studies, and multidisciplinary cancer treatment, supporting practice-changing research across tumour types.
Prof. Barlesi has fostered collaboration between hospital, university, and research networks, notably co-founding the Marseille Immunopôle French Immunology network and organizing PIONeeR, a major project to improve understanding of resistance to immunotherapy in lung cancer. His strategic vision, focus on innovation, and ability to bridge research with patient care have strengthened Gustave Roussy’s position as a leading cancer center. He has received Heine H. Hansen Prize from ESMO and IASLC in 2018.
The 100 CEOs featured here reflect the diversity and complexity of modern oncology leadership. In 2025, some lead the world’s largest cancer institutions; others guide specialized societies or emerging innovators. What unites them is responsibility: for millions of patients, for the integrity of science, and for the future direction of cancer care globally.
This list is not a celebration of power, but a recognition of stewardship, accountability, and impact – and of the leaders whose choices continue to shape the fight against cancer. For the many deserving individuals not mentioned in this list, we will continue to acknowledge, honor and elevate your voices in our daily publications from across the world.
See the full list of The 100 Influential CEOs in Oncology in 2025 and stay tuned for other special category nominations.
