David Scott is the Director of Cancer Grand Challenges, a global research initiative co-founded by Cancer Research UK and the U.S. National Cancer Institute to tackle some of the most complex and high-impact problems in cancer research. He has led the strategic development and delivery of the initiative since its inception, drawing on more than 20 years of experience in research funding and management, including senior leadership roles at Cancer Research UK and earlier positions at Imperial College London and the Wellcome Trust. In addition to his responsibilities with Cancer Grand Challenges, Scott serves as Executive Director of American Friends of Cancer Research, a U.S. nonprofit partner organization that supports the initiative’s work and broader global cancer research collaborations.
Under Scott’s leadership, Cancer Grand Challenges has grown into a major global platform for interdisciplinary team science, investing around USD 400 million to date in research that crosses traditional boundaries and unites investigators from multiple countries to address transformational challenges in cancer biology, prevention, and treatment. The initiative supports large multidisciplinary research teams enabling them to pursue bold ideas in areas such as early-onset cancers, cancer inequities, pediatric solid tumors, and T-cell immunobiology. These efforts reflect a strategic emphasis on enabling high-risk, potentially high-impact science that may drive breakthroughs in understanding and ultimately improving outcomes for people affected by cancer.
The 100 CEOs featured here reflect the diversity and complexity of modern oncology leadership. In 2025, some lead the world’s largest cancer institutions; others guide specialized societies or emerging innovators. What unites them is responsibility: for millions of patients, for the integrity of science, and for the future direction of cancer care globally.
This list is not a celebration of power, but a recognition of stewardship, accountability, and impact – and of the leaders whose choices continue to shape the fight against cancer. For the many deserving individuals not mentioned in this list, we will continue to acknowledge, honor and elevate your voices in our daily publications from across the world.
See the full list of The 100 Influential CEOs in Oncology in 2025 and stay tuned for other special category nominations
