Yan Leyfman: Ammonia – A Hidden Obstacle in Cancer Immunotherapy
Yan Leyfman, Co-founder and executive director of MedNews Week, posted on LinkedIn:
“Ammonia: A Hidden Obstacle in Cancer Immunotherapy.
Immunotherapy has transformed cancer treatment, but the tumor microenvironment remains a major challenge.
This study reveals that ammonia, a by-product of cancer cell metabolism, suppresses NK and T cell function, reducing the effectiveness of CAR-NK and CAR-T therapies.
Key Findings:
- Ammonia weakens NK and T cells, impairing their ability to kill cancer cells.
- It disrupts perforin maturation, a key weapon for immune cells.
- By increasing pH in lysosomes, ammonia hampers immune response.
These insights highlight a new mechanism of tumor immune escape, paving the way for future strategies to overcome ammonia’s effects in cancer treatment. ”
Authors: Joanna Domagala, Tomasz M. Grzywa, Iwona Baranowska, Magdalena Justyniarska, Ryan Tannir, Agnieszka Graczyk-Jarzynka, Aleksandra Kusowska, Maria Lecka, Marcin Poreba, Klaudyna Fidyt, Katsiaryna Marhelava, Zofia Pilch, Lea K. Picard, Tomasz Wegierski, Kamil Jastrzebski, Marta Krawczyk, Marta Klopotowska, Monika Granica, Doris Urlaub, Szymon Hajduk, Alexandra Neeser, Spencer Moros, Pawel Kozlowski, Malgorzata Bobrowicz, Marta Miaczynska, Leyuan Ma, Carsten Watzl, Magdalena Winiarska
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