Yan Leyfman: Enhancing Immunity to Fight Cancer Metastasis
Yan Leyfman, Co-founder and Executive Director of MedNews Week, shared a post on LinkedIn:
“New Research Insight: Enhancing Immunity to Fight Cancer Metastasis.
A recent study reveals that aspirin and COX-1 inhibitors may help prevent cancer metastasis by boosting T cell immunity. Researchers found that platelet-derived thromboxane A2 (TXA2) suppresses T cells, but blocking this pathway with aspirin frees T cells to attack metastatic cancer cells.
Key Findings:
TXA2 triggers an immunosuppressive pathway through ARHGEF1 in T cells.
Deleting Arhgef1 in mice led to immune-mediated rejection of lung and liver metastases.
Aspirin and COX-1 inhibitors reduced metastasis by enhancing T cell function.
These findings offer fresh insights into aspirin’s anti-metastatic properties and could pave the way for new immunotherapies to prevent cancer spread.”
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
Authors: Jie Yang et al.
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