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Yan Leyfman: Can Macrophages Revolutionize Cancer Immunotherapy?
Jul 9, 2025, 14:14

Yan Leyfman: Can Macrophages Revolutionize Cancer Immunotherapy?

Yan Leyfman, Co-founder and Executive Director of MedNews Week, shared a post on X:

“Can macrophages revolutionize cancer immunotherapy?

Macrophages naturally infiltrate tumors, reshape the TME, phagocytose cancer cells, and activate T cells – making them powerful tools for next-gen therapy.

Enter CAR-Ms: Chimeric Antigen Receptor–engineered Macrophages.

In early trials and preclinical studies, CAR-Ms:

Kill tumors via phagocytosis

– Modulate immunosuppressive TMEs
– Induce endogenous anti-tumor T cell responses
– Show low CRS risk vs CAR-T cells
– Infiltrate solid tumors more efficiently than CAR-T/NK cells

Key strategies boosting efficacy:

Anti-CD47 (“don’t eat me” blockade)
Anti-PD-1 combination
Proinflammatory signaling (e.g. IL-12, IFN-γ)
In vivo delivery via LNPs or hydrogel platforms

CAR-Ms may solve CAR-T’s biggest limitations:

— Toxicity
— Cost
— Solid tumor resistance

Future focus:

Safer vectors (CRISPR > lentivirus)
Off-the-shelf or in vivo platforms

Targeting oncogenic drivers, not just surface antigens

Read more about how CAR-Ms may reshape the future of immunotherapy.”

Title: Engineering myeloid cells for cancer immunotherapy

Authors: Jianzhu Chen, Yingjie Zhao, Xiaotong Chen, Jiayao Yan, Fuguo Liu, Rizwan Romee

Read Full Article.

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