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Reanalysis of Urothelial Cancer Chemoimmunotherapy Trials With Differential Censoring
opmed.doximity.com
Jan 29, 2025, 07:56

Reanalysis of Urothelial Cancer Chemoimmunotherapy Trials With Differential Censoring

Laura Bukavina, Urologic Oncologist at Cleveland Clinic Urology, shared a post on X:

“When control patients drop out for better options, outcomes get skewed equals perceived inferiority bias

In Bladder Cancer trials this bias inflated PFS/OS for chemo + IO. Adjustments erased OS (nivolumab, CheckMate901) and PFS (pembrolizumab, KEYNOTE-361). RCT are not perfect.”

Reanalysis of Urothelial Cancer Chemoimmunotherapy Trials With Differential Censoring

Authors: Tomer Meirson, Jonathan Ofer,  Noa Zimhony-Nissim, Avital Bareket-Samish,  Gal Markel,  Victoria Neiman, Nathan Cherny, Daniel A. Goldstein,  Bishal Gyawali, Ian Tannock, Eli Rosenbaum.

Reanalysis of Urothelial Cancer Chemoimmunotherapy Trials With Differential Censoring

 

Avital Bareket-Samish Bishal Gyawali cancer Daniel A. Goldstein Eli Rosenbaum Gal Markel Ian Tannock Jonathan Ofer Laura Bukavina Nathan Cherny Noa Zimhony-Nissim OncoDaily Oncology Tomer Meirson Victoria Neiman
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