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Raffaele Colombo: Sacituzumab Govitecan (SG) vs Sacituzumab Tirumotecan (Sac-TMT)
Raffaele Colombo/LinkedIn
Apr 12, 2025, 02:19

Raffaele Colombo: Sacituzumab Govitecan (SG) vs Sacituzumab Tirumotecan (Sac-TMT)

Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks, shared a post on X:

“Sacituzumab govitecan (SG) vs sacituzumab tirumotecan (Sac-TMT)

= antibody
≈ DAR (7.6 vs 7.4)
≠ conjugation chemistry (maleimide vs pyrimidine)
≈ linker (except conjugation part)
= carbonate cleavable group
≠ payload structure and properties (SN-38 vs KL610023).”

Raffaele Colombo

 

cancer OncoDaily Oncology Raffaele Colombo Sacituzumab govitecan Sacituzumab Tirumotecan
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