Raffaele Colombo/LinkedIn
Apr 12, 2025, 02:19
Raffaele Colombo: Sacituzumab Govitecan (SG) vs Sacituzumab Tirumotecan (Sac-TMT)
Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks, shared a post on X:
“Sacituzumab govitecan (SG) vs sacituzumab tirumotecan (Sac-TMT)
= antibody
≈ DAR (7.6 vs 7.4)
≠ conjugation chemistry (maleimide vs pyrimidine)
≈ linker (except conjugation part)
= carbonate cleavable group
≠ payload structure and properties (SN-38 vs KL610023).”
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