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Paul Brennan: Final Version of Nature Paper on Mutational Signatures for Colorectal Cancer
Jul 7, 2025, 13:12

Paul Brennan: Final Version of Nature Paper on Mutational Signatures for Colorectal Cancer

Paul Brennan, Head of Section at International Agency for Research on Cancer / World Health Organization, shared IARC‘s post on X, adding:

“Final version of Nature paper on mutational signatures for colorectal cancer.

Important implications for early onset colorectal cancer.

Check out paper or video below.

Thanks as always to Cancer Grand Challenges + team Wellcome Sanger Institute and Ludmil, Marcos.”

Title: Geographic and age variations in mutational processes in colorectal cancer

Authors: Marcos Díaz-Gay, Wellington dos Santos, Sarah Moody, Mariya Kazachkova, Ammal Abbasi, Christopher D. Steele, Raviteja Vangara, Sergey Senkin, Jingwei Wang, Stephen Fitzgerald, Erik N. Bergstrom, Azhar Khandekar, Burçak Otlu, Behnoush Abedi-Ardekani, Ana Carolina de Carvalho, Thomas Cattiaux, Ricardo Cortez Cardoso Penha, Valérie Gaborieau, Priscilia Chopard, Christine Carreira, Saamin Cheema, Calli Latimer, Jon W. Teague, Anush Mukeriya, David Zaridze, Riley Cox, Monique Albert, Larry Phouthavongsy, Steven Gallinger, Reza Malekzadeh, Ahmadreza Niavarani, Marko Miladinov, Katarina Erić, Sasa Milosavljevic, Suleeporn Sangrajrang, Maria Paula Curado, Samuel Aguiar, Rui Manuel Reis, Monise Tadin Reis, Luis Gustavo Romagnolo, Denise Peixoto Guimarães, Ivana Holcatova, Jaroslav Kalvach, Carlos Alberto Vaccaro, Tamara Alejandra Piñero, Beata Świątkowska, Jolanta Lissowska, Katarzyna Roszkowska-Purska, Antonio Huertas-Salgado, Tatsuhiro Shibata, Satoshi Shiba, Surasak Sangkhathat, Taned Chitapanarux, Gholamreza Roshandel, Patricia Ashton-Prolla, Daniel C. Damin, Francine Hehn de Oliveira, Laura Humphreys, Trevor D. Lawley, Sandra Perdomo, Michael R. Stratton, Paul Brennan and Ludmil B. Alexandrov

Read the Full Article on Nature

Paul Brennan: Final Version of Nature Paper on Mutational Signatures for Colorectal Cancer

Quoting IARC’s post:

“In a new video, Dr IARC’s Paul Brennan presents the latest findings which may explain why Colorectal Cancer is rapidly increasing in young adults.

Watch and learn what the team found, how they found it, and what it may mean for cancer prevention and early detection.”

More posts featuring Colorectal Cancer.