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Patrick Hwu: Can cancer-associated fibroblasts stimulate the immune system?
Apr 7, 2025, 18:21

Patrick Hwu: Can cancer-associated fibroblasts stimulate the immune system?

Patrick Hwu, President and CEO of Moffitt Cancer Center, shared an article by Junquan Song et al. on LinkedIn:

Can cancer-associated fibroblasts stimulate the immune system?

While some fibroblasts promote tumor growth, a recent study describes a population of antigen presenting cancer-associated fibroblasts in gastric cancer patients capable of stimulating T cells to kill cancer cells.

This highlights the heterogeneity of the tumor microenvironment and may lead to strategies to enhance this immune stimulating fibroblast population to improve cancer immunotherapy.

Here’s a link to the full study”

Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response

Authors: Junquan Song, Rongyuan Wei, Chenchen Liu, Zhenxiong Zhao, Xuanjun Liu, Yanong Wang, Fenglin Liu and Xiaowen Liu.

Patrick Hwu

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