Introducing the Genome Organization and Gene Regulation Group led by Nils Krietenstein – Danish Cancer Institute
Danish Cancer Institute shared a post on LinkedIn:
“Introducing the Genome Organization and Gene Regulation Group.
The Krietenstein Group is dedicated to uncovering how the 3D folding of genomes shapes gene regulation in health and disease, including cancer.
Each human cell contains 2 meters of DNA, intricately packed into a nucleus just 10 micrometers in diameter. While only 1–2% of this DNA encodes proteins, the vast non-coding regions play essential regulatory roles. Many cancer-causing mutations are found in these regions, affecting gene expression rather than altering the genes themselves.
Led by Associate Professor Nils Krietenstein, the group studies how genome architecture and distant regulatory elements, called enhancers, control gene activity. These mechanisms are vital for development but can be disrupted by mutations or epigenetic changes, leading to cancer. Using cutting-edge 3D genomics, the Krietenstein Group maps genome structure at ultra-high resolution to understand how non-coding mutations drive malignant gene expression.”
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