Moffitt Cancer Center – Potential avenues for toxicity prevention and therapeutic optimization in high-risk patients
Moffitt Cancer Center shared on LinkedIn:
“In a packed ASH24 session, Doris Hansen, presented a comprehensive analysis of pre-treatment biomarkers associated with toxicity and durable response in idecabtagene vicleucel therapy for relapsed/refractory Multiple Myeloma patients.
Pre-treatment disease burden and inflammation pose a high risk for ICANS, whereas higher cell doses associated with high grade CRS.
Pre-treatment M-MDSCs and markers of T cell exhausted associate with reduced CAR-T expansion. DR was linked to lower PCB and favorable BM profiles: higher CD4:CD8 ratios, the presence of cytotoxic NK cells, and more stem central memory CD8+ T cells.
These findings provide insights into potential avenues for toxicity prevention and therapeutic optimization in high-risk patients.
Additional larger studies are warranted with longer follow-up to understand the complex relationships between inflammation, immunity, toxicity and efficacy among RRMM patients treated with idi-cel.”
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ESMO 2024 Congress
September 13-17, 2024
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ASCO Annual Meeting
May 30 - June 4, 2024
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Yvonne Award 2024
May 31, 2024
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OncoThon 2024, Online
Feb. 15, 2024
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Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023