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Minhua Chu: The First Clinical Trial Combining Ivonescimab With an ADC has Received Approval
Minhua Chu/LinkedIn
Aug 6, 2025, 09:00

Minhua Chu: The First Clinical Trial Combining Ivonescimab With an ADC has Received Approval

Minhua Chu, Managing Partner at TransitionValue Partner, shared a post on X:

“Therapeutics’s B7H3 ADC YL201, in combination with Akeso‘s PD-1/VEGF bispecific antibody ivonescimab, has received approval for a clinical trial application for multiple solid tumors.

This marks the first clinical trial combining ivonescimab with an ADC.

Last month, after Akeso‘s first bispecific ADC drug, targeting TROP-2/Nectin-4 (AK146D1), completed its first Phase 1 dosing in Australia, the company introduced the concept of ‘IO+ADC’ 2.0.

YL201 has initiated two Phase 3 clinical trials.”

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