Miguel Bronchud/LinkedIn
Jun 30, 2025, 12:29
Miguel Bronchud: FLT1-Positive EVs Drive Angiogenesis and Metastasis in Nasopharyngeal Carcinoma
Miguel Bronchud, Co-Founder and Advisory Board at Regenerative Medicine Solutions, shared a post on LinkedIn:
“Re deployment in Naso Pharyngeal Cancers of placental neo angiogenesis and spread of immune suppression “metastatic” niches?
The placenta releases extracellular vesicles (EVs) containing proteins like FLT1 (also known as sFlt-1), which play a role in regulating placental function and can be involved in pregnancy complications like preeclampsia. These EVs, including exosomes and microvesicles, are found in the maternal circulation and can impact maternal physiology.
These EVs carry a variety of bio active molecules, including proteins, lipids, and nucleic acids, that can influence maternal physiology. Fms-like tyrosine kinase 1 (FLT1), also known as soluble FLT1 (sFlt-1), is a protein produced by the placenta. It acts as a decoy receptor for vascular endothelial growth factor (VEGF), a protein important for blood vessel formation.
See-recently published Oncogene paper by the Chinese School of Life Sciences, Sun Yat-sen University, Guangzhou, China and the Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen, China:
“FLT1-enriched extracellular vesicles induce a positive feedback loop between nasopharyngeal carcinoma cells and endothelial cells to promote angiogenesis and tumour metastasis”
FLT1-enriched EVs promoted NPC metastasis through the PI3K/AKT pathway and increased tumour angiogenesis, tumour growth, and distant lung and liver metastasis of NPC in xenografted mice. This effect was achieved through the delivery and upregulation of FLT1 in both endothelial and NPC cells. Thus, their findings reveal that FLT1-enriched EVs induce a positive feedback loop between NPC cells and endothelial cells to promote tumour angiogenesis and tumour metastasis.”
Title: FLT1-enriched extracellular vesicles induce a positive feedback loop between nasopharyngeal carcinoma cells and endothelial cells to promote angiogenesis and tumour metastasis
Authors: Fei Li, Lin Song, Yue He, Peiling Chen, Jiasheng Wang, Maozhen Zeng, Chunmou Li, Junru Chen, Haisheng Chen, Qiqi Guo, Jiaxi Fan, Xuan Huang, Qi Wang, Qing Zhang
Read The Full Article at Oncogene.
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