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Matthew Kurian: DESTINY-Breast09 may change the landscape of first-line treatment for HER2+ MBC
Apr 21, 2025, 08:07

Matthew Kurian: DESTINY-Breast09 may change the landscape of first-line treatment for HER2+ MBC

Matthew Kurian, Physician at St. Elizabeth Healthcare and Assistant Professor of Medicine at the University of Kentucky College of Medicine, shared a post on LinkedIn by Jame Abraham, Chairman of the Department of Hematology and Medical Oncology at Cleveland Clinic, adding:

“I share Jame Abraham, M.D. FACP’s enthusiasm! DESTINY-Breast09 may change the landscape of first-line treatment for HER2+ metastatic breast cancer in over a decade!

AstraZeneca and Daiichi Sankyo just announced that ENHERTU (trastuzumab deruxtecan) + pertuzumab significantly improved PFS over the current THP standard (taxane + trastuzumab + pertuzumab) in the first-line setting.

Full data coming soon at an upcoming meeting!”

Quoting Jame Abraham’s post:

“Exciting news from AZ Press Release – DESTINY 09! The data shows significant improvement in PFS for Enhertu + Pertuzumab compared to THP in first-line MBC.

This could potentially be practice-changing once we have all the data available. Stay tuned for more updates!”

Matthew Kurian: DESTINY-Breast09 may change the landscape of first-line treatment for HER2+ MBC

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