Kunal Jobanputra/LinkedIn
May 5, 2025, 04:12
Kunal Jobanputra: Differences between CISH and cell surface checkpoints
Kunal Jobanputra, Consultant Medical Oncologist at Saifee Hospital, posted on X:
“CISH – Cytokine-Inducible SH2-containing protein, an intracellular immune checkpoint in T cells.
- Part of the suppressor of cytokine signaling (SOCS) family.
- Triggered by TCR ligation or cytokines (IL-2, IL-3, GM-CSF, EPO).
Function: Inhibits T-cell activation by degrading signaling intermediates (e.g., PLC-gamma-1).
- Reduces cytokine release, proliferation, and T-cell survival.
- Operates inside the cell, unlike surface checkpoints (e.g., PD-1, CTLA-4).
- High CISH levels in TILs linked to lower reactivity to tumor neoantigens.
Differences between CISH and cell surface checkpoints.”
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