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Kohei Shitara։ DG04 Took 3.5+ Years for HER2 Confirmation
Kohei Shitara/X
Jul 26, 2025, 07:32

Kohei Shitara։ DG04 Took 3.5+ Years for HER2 Confirmation

Kohei Shitara, Director of National Cancer Center Hospital East, shared a post on X:

“DG04 officially published NEJM, ASCO.

This comes 10 years after my first phase 1 patient. DG04 took 3.5+ years due to <15% HER2+ and fresh biopsy to confirm HER2. Grateful for global effort—hoping this expands T-DXd access worldwide.”

Title: Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer

Authors: Kohei Shitara, Eric Van Cutsem, Mahmut Gümüş, Sara Lonardi, Christelle de la Fouchardière, Clélia Coutzac, Jeroen Dekervel, Daniel Hochhauser, Lin Shen, Wasat Mansoor, Bo Liu, Lorenzo Fornaro, Min-Hee Ryu, Jeeyun Lee, Cátia Faustino, Jean-Philippe Metges, Josep Tabernero, Fábio Franke, Yelena Y. Janjigian, Fabricio Souza, Lori Jukofsky, Yumin Zhao, Takahiro Kamio, Aziz Zaanan, Filippo Pietrantonio

Read full article on NEJM.

Kohei Shitara։ DG04 Took 3.5+ Years for HER2 Confirmation

More post featuring Kohei Shitara on OncoDaily.

ASCO Aziz Zaanan Bo Liu cancer Cátia Faustino CHRISTELLE DE LA FOUCHARDIERE Clelia Coutzac Daniel Hochhauser Eric van Cutsem Fabio Franke Fabricio Souza Filippo Pietrantonio Jean-Philippe Metges Jeeyun Lee Jeroen Dekervel Josep Tabernero Kohei shitara Lin Shen Lorenzo Fornaro Lori Jukofsky Mahmut Gümüş Min-Hee Ryu NEJM OncoDaily Oncology Sara Lonardi Takahiro Kamio Wasat Mansoor Yelena Y. Janjigian Yumin Zhao
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