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Kefah Mokbel: Does DCIS require surgery?
Jul 10, 2025, 09:24

Kefah Mokbel: Does DCIS require surgery?

Kefah Mokbel, Chair of Breast Cancer Surgery at The London Breast Institute, shared a post on LinkedIn:

“Does DCIS require surgery?

In a cohort of patients who did not receive initial surgery for DCIS, the 8 year cumulative incidence of invasive cancer in the same breast varied between 8% for low risk and 14% for high risk. Effective risk stratification tools and shared decision making are essential for this patient population.

Although this descriptive study alone does not change practice, the data offer two key insights for patients and their clinicians.

First, DCIS should not automatically be viewed as “cancer” with the associated fear of spread and death. I always tell my patients that DCS is ‘pre-cancer’. For patients with low-risk disease and other health issues that may delay surgery, active monitoring is unlikely to pose significant oncologic risk.

Second, the eight-year risk of a cancer event after DCIS diagnosis remains below 11%, similar to the risk with other high-risk histologies like atypia. This level of risk should inform discussions about treatment options and highlights the importance of patient education and shared decision-making, especially for low-risk DCIS.

Cancer outcomes in women without upfront surgery for ductal carcinoma in situ: observational cohort study.”