Structural insights into human topoisomerase 3β DNA and RNA catalysis and nucleic acid gate dynamics
NCI Center for Cancer Research shared a post on LinkedIn:
“Type IA topoisomerases (TopoIAs) are present in all living organisms. They resolve DNA/RNA “tangles” by breaking and rejoining single-stranded DNA/RNA segments and allowing the passage of another nucleic acid segment through the break. CCR researchers revealed in a new study published in Nature how TOP3B, one of these topoisomerases, catalyzes both DNA and RNA relaxation, while TOP3A acts only on DNA.
CCR’s Developmental Therapeutics Branch (DTB) focuses on cancer-specific genomic and epigenomic alterations, oxidative signaling, molecular pharmacology and drug resistance. Through the understanding of molecular mechanisms in healthy cells, the DTB provides insights for scientists to understand how these processes may go awry and cause diseases like cancer.
Structural insights into human topoisomerase 3β DNA and RNA catalysis and nucleic acid gate dynamics
Authors: Xi Yang, et al.
Image: Cryo-EM volume of cTOP3B-Y336F bound to gapped DNA (after applying a gaussian filter) in orthogonal views. Colored regions highlight the protein segments of the core complex of TOP3B-TDRD3 (cTOP3B) resolved from the cryo-EM volumes.
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