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Aug 5, 2025, 10:09
George Kumar: How TR cryo-EM is Revolutionizing Structural Biology
George Kumar, Senior Director. Medical Diagnostics Pan Tumor & GI Cancers at AstraZeneca, shared on LinkedIn:
“Published in Nature (June 2025), this technology feature explores how time-resolved cryo-electron microscopy (TR cryo-EM) is revolutionizing structural biology by capturing rapid protein movements at near-atomic resolution.
Key Highlights:
- TR cryo-EM can visualize dynamic protein conformations on millisecond to microsecond timescales
- Enables ‘freeze-frame’ snapshots of enzymes, receptors, and molecular machines in action
- Offers insights into druggable intermediate states often missed by traditional static methods
However, its adoption is limited by the need for specialized equipment, complex workflows, and deep technical expertise.
As this technology evolves, it holds enormous promise for unlocking new frontiers in protein dynamics, drug discovery, and molecular design.”
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