Dissecting the Role of FOXR2 in the Oncogenesis of Diffuse Intrinsic Pontine Glioma
Caryn Lerman, Director of Norris Comprehensive Cancer Center at Keck Medicine of USC, shared a post on LinkedIn:
“Diffuse intrinsic pontine glioma (DIPG) is a deadly pediatric brain cancer.
Despite radiation treatment, the current standard of care, almost all children diagnosed with the disease succumb to it with a median survival of 12 months. There have been few advancements in treatment, and current treatment has no curative intent.
Thanks to an award from the Alex’s Lemonade Stand Foundation, Dr. Jessica Tsai, a member of the USC Norris Cancer Control Research Program, will work to develop new therapeutic strategies to improve the terrible outcomes for these children and improve quality of life for patients and their families by looking at the FOXR2 gene, a gene that is turned on in DIPGs. To help us understand how we can therapeutically target the FOXR2 gene, she will investigate how this gene contributes to growth of DIPG cells.
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