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David Heredia: Not all Lung adenocarcinomas respond the same
Photo: Depositphotos
Apr 19, 2025, 06:30

David Heredia: Not all Lung adenocarcinomas respond the same

David Heredia, Thoracic oncologist at Punta Médica Hospital, posted on X:

“Not all Lung adenocarcinomas (LUAD) respond the same.

Mucinous LUAD = 10% of cases, often KRAS+, TTF1–, PD-L1 low

Worse outcomes across therapies:

  • ICI ORR: 8.4% vs 25.9%
  • IO+chemo OS: 11.4 vs 19.6 mo
  • KRASG12C OS: 6.8 vs 10.8 mo

Histology matters.”

“Lung adenocarcinomas with mucinous histology: clinical, genomic, and immune microenvironment characterization and outcomes to immunotherapy-based treatments and KRASG12C inhibitors.”

Authors: A. Di Federico et al.

David Heredia: Not all Lung adenocarcinomas respond the same

cancer David Heredia lung adenocarcinoma Lung cancer OncoDaily Oncology
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