Photo: Depositphotos
May 26, 2025, 06:59
Chrysothemis Brown: A Wave of Thetis Cells Imparts Tolerance to Food Antigens Early in Life
Chrysothemis Brown, Assistant Member at Memorial Sloan Kettering Cancer Center, posted on LinkedIn:
“Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens.
This was a fantastic team effort, led by Vanja Cabric and Yollanda Parisotto in my laboratory. We asked two questions: First, do Thetis cells instruct tolerance to food antigens? Second, does the developmental wave of Thetis cells in early life underly the window of opportunity for oral tolerance that has been described in children with food allergy?
Using several new genetic approaches, we found that a subset of Thetis cells, TC IV, is uniquely able to induce food-specific pTreg differentiation and oral tolerance. Excitingly, we found that a developmental wave of Thetis cells at the time of weaning is associated with a window of opportunity for enhanced pTreg generation in response to food antigens.
Our findings indicate that TC IV may represent a therapeutic target for the treatment of food-associated allergic and inflammatory diseases.
A huge thank you to all of the lab members that contributed to this study, our collaborators and funders.”
Title: A Wave of Thetis Cells Imparts Tolerance to Food Antigens Early in Life
Authors: Vanja Cabric, Yollanda Franco Parisotto, Tyler Park, Blossom Akagbosu, Zihan Zhao, Yun Lo, Gayathri Shibu, Logan Fisher, Yoselin A. Paucar Iza, Christina Leslie, Chrysothemis C. Brown
Read The Full Article at Science.
-
Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023
May 26, 2025, 06:48
May 26, 2025, 06:41
May 26, 2025, 06:10
May 26, 2025, 06:00
May 25, 2025, 17:30